What is Kisspeptin?
Kisspeptin is produced from the brain, specifically the hypothalamus. This causes a range of cell to cell communication, which leads to the production of the hormones, namely, luteinizing hormone and follicle-stimulating hormone from the pituitary gland. This is then released into the bloodstream.
Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) plays an essential role in sexual development and functioning. In women, these hormones help regulate the menstrual cycle. It also triggers the release of an egg from the ovary. This is known as ovulation. In men, these hormones cause the testicles to make testosterone, which is essential for producing sperm.
Kisspeptin has a secondary function that is not related to hormones. Its original name, metastin, points to its ability to prevent cancer from spreading in the body.
What happens to the body when It’s levels are too high or too low?
Having high levels of Kisspeptin is not associated with any adverse conditions or symptoms. However, research shows that high kisspeptin levels in the body during childhood can potentially lead to having the early onset of puberty. Furthermore, during pregnancy, high levels of it can be evidently observed.
On the other hand, having low levels of Kisspeptin in the system is found to have a contrary effect on the body. Specifically, this can cause infertility in women. There is evidence that Kisspeptin injection could trigger the ovulation process and induce oocyte maturation during the controlled ovarian hyperstimulation. With this, artificial insemination and in vitro fertilization would have a high chance of success. Furthermore, low kisspeptin levels in childhood could potentially result in the delay of the onset of puberty.
Uses of Kisspeptin
The start of puberty is marked by a surge in gonadotropin secretion. This leads to sexual maturity and the ability to reproduce. Gonadotropin secretion is brought about and regulated by gonadotropin-releasing hormone (GnRH). GnRH leads to the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This then primarily targets the gonads to trigger puberty and reproduction. The crucial event that leads to the onset of puberty is the activation of GnRH neurons. This event is thought to involve kisspeptin signaling.
Several types of research have supported the findings that its addition to biological systems can bring about the release of LH and FSH. In addition to this, the release of these gonadotropins has proven to be dose-dependent. A more significant addition of kisspeptin peptide resulted in a greater release of LH and FSH. Hence, Kisspeptin administration was found to induce one of the most potent effects on the gonadotropin system.
Kisspeptin plays a role in tumor suppression. Studies suggest that it is an essential regulation factor to determine whether the cancer cell will be metastatic or not. In other words, when Kisspeptin is administered in cancer cells, the tumor stays intact and does not spread or grow.
Is this for you?
If you are one of the people struggling with fertility, your kisspeptin levels may be one reason for your problem. Talk to your doctor about this and learn whether this treatment could be beneficial for you.
If you have questions or concerns about this particular hormone, talk to a qualified endocrinologist. If you do not have an endocrinologist, find one today to better understand Kisspeptin, its role in the body, and how it affects your hormonal health.
Clinic in Tennessee that offers Kisspeptin
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